Marfan syndrome is a genetic disorder that affects the body’s connective tissue, which plays a key role in supporting organs, blood vessels, bones, and other structures. People with Marfan syndrome often have distinct physical characteristics such as tall stature, long limbs, and slender fingers, but the condition can vary widely from one individual to another. Since connective tissue is involved in many bodily systems, Marfan syndrome can impact the heart, eyes, skeleton, and other areas in different ways.